In this paper we follow the pathway sentient informational reality couples to our well-known mass/matter/energy world, in a well-integrated inter-dimensional process. Pure information in its pre-energetic aspect couples to subquantum (SQ) units and combinatorials of increasing complexity, able to transgress the ZPE (Zero-point energy) barrier between nonlocal information fields and local quantum processes, being stored and vehiculated by pre-quantum subtle energy variants. The link between these ontologically different domains is provided by the Compton-radius vortex configurations operating at the level of sub-quarks across all the periodic table of elements. Life as inherent condition of manifestation results as the conscious aspect of matter. The fundamental coupling mechanism between non-local and material regimes is supported both by compelling evidence supplied in bio-energetic physics and by recent mathematical proves.