Genomic analysis of APP, PSEN1 and MAPT genes involved in the pathogenesis of Alzheimer’s disease

Neurodegenerative diseases, such as Alzheimer’s disease or other forms of dementia, represent a major challenge for global public health, and understanding the genetic mechanisms involved is essential for the development of diagnostic and treatment strategies. This work aims to study three key genes involved in the pathogenesis of neurodegeneration: APP (Amyloid Precursor Protein), PSEN1 (Presenilin 1) and MAPT (Microtubule Associated Protein Tau). The aim of the research is to analyze the classification of these genes, pathogenic genetic variations and frequent polymorphisms, as well as their impact on physiological and pathological processes. The methodology is based on a comparative analysis of data from the specialized literature and from genetic and expression databases, including GTEx, Human Protein Atlas, STRING and GeneMANIA platforms, as well as integrations from genome-wide association studies (GWAS).

The Evolution of Global Warming: Tipping Points, Human Inaction, and Future Scenarios

Global warming is an unequivocal reality, and overwhelming scientific evidence attributes this rapid climate change to human activities. Since the Industrial Revolution, humans have poured billions of tons of carbon dioxide (CO₂) and other greenhouse gases into the atmosphere, trapping heat and raising Earth’s temperature at an unprecedented rate. The scientific consensus is clear: human-induced climate change is real, measurable, and accelerating, and its potential consequences pose profound challenges for the future of civilization. On one path, humanity manages to unite in an unprecedented effort to cut emissions, protect ecosystems, and innovate towards sustainability – in time to avert the worst outcomes. On the other, we continue with half-hearted measures and discord, thereby forfeiting our last chance to keep climate change within controllable bounds.

A Different Approach to the Dynamo Mechanism

The study of the Earth’s magnetic field is the subject of a continuous and complex research effort. Practically, almost all studies on the geomagnetic field are based on the heat provided by the inner core. Other sources of heat are also invoked, such as the decay of radioactive elements, gravitational force, chemical reactions. However, solutions are still sought for a coherent understanding of the geodynamo mechanism that leads to the generation of the Earth’s magnetic field in the rotating fluid outer core and good conductor of electricity. After studying the elements that participate in the operation of the dynamo mechanism through the prism of the basic principles of physics, an operating model was found that provides a coherent understanding of the geodynamo, based on the phenomena that occur at the place of contact between the lower mantle and the outer core. At the same time, this model reconfirms and consolidates the dynamo theory formulated by Sir Edward Crisp Bullard.

Russia’s Gopnik Subculture: aktsiia on the street and “correct” masculinity in post-Soviet Russia

The paper analyses a distinct feature of Russia in the 1990s that had a significant impact on the disarray caused by the collapse of the Soviet Union. Young Gopnik clothed in sportswear travelled from Russia’s rural districts to the cities, and these troublesome young men, who were regarded as the proper strain of masculinity, increased rapidly at a period of national turmoil. The article is based on a theoretical framework that draws attention to the concept of social disorganization theory, strain theory and cultural deviance theory. Although the group dissolved from the Russian political landscape, their worldviews remained influential in Russian culture.

The Baryonic Charge Hypothesis of Gravity

This article proposes a new hypothesis regarding gravity, suggesting that the gravitational field is not generated by mass, but by the baryonic charge of a body.
Classical theory considers gravity as an emergent property of mass; however, this model explores the possibility that interactions between baryons are responsible for the curvature of space. In this context, the potential existence of an anti-gravitational field associated with antimatter is also discussed. The article further explores the possibility of unifying the strong nuclear force with gravity as scalar manifestations of the same space-time curvature.

AI as a Creative Tool: Tracing Its Role in Interactive Documentary Evolution

This article explores the transformative role of artificial intelligence (AI) in the evolution of interactive documentary filmmaking. AI technologies are changing the ways of presenting stories as well as the overall experience, which is possible with artificial intelligence technologies. In the article, the author focuses on the following aspects of AI implementation in interactive documentaries: pre-production, design, prototyping, and post-production, which encompasses GPT models, AI avatars, voice cloning, and virtual and augmented reality.

Nabokov’s narration in Lolita

Stoian, Teodora (2025), Nabokov’s narration in Lolita, Cunoașterea Științifică, 4:2, 121-127, https://www.cunoasterea.ro/nabokovs-narration-in-lolita/   Abstract “Lolita” is a first-person confessional narrative, composed in a jail on the verge of a fatal “coronary thrombosis” (L3) that is heart failure by Humbert Humbert, an intelligent European immigrant. Humbert’s story is prefaced by a Foreword written by John Ray Ph.D, who introduces himself as the editor of the manuscrispt. Keywords: Humbert Humbert, Lolita, narration, John Ray, Vladimir Nabokov Narațiunea lui Nabokov în Lolita Rezumat … Read More

Rebellion in George Orwell’s “1984”

Winston Smith’s rebellion in “1984” implies the struggle for instinctual freedom against the conformity of totalitarian state. Orwell’s Winston Smith is the last Adam, reenacting the myth of the Fall, following his Eve into disobedience against God. Thus, the misfortunes of Winston, Orwell’s anti-hero reveal the political system of the ruling state of Oceania in 1984.

Interactive Documentaries and the Transformation of Artificial Intelligence

Digital technologies continue to regenerate and metamorphose the methods of producing interactive documentaries and how their audiences consume them in the 21st century. In addition, media practitioners with specialties in producing interactive documentaries are still creating new technological approaches to taint various worldly perceptions while introducing additional strategies for improving efficiency in the production process. Most importantly, contemporary digital innovations such as documentary games, websites, desktop multimedia applications, non-fictional works, and interactive installations explore these types of documentaries and challenge their present formats.

„The Sahara of Romania” – The Southern Romanian Plain

One of the most sensitive regions of the country – the south of the Romanian Plain – is starting to be renowned for the onset of desertification. The intensification of land degradation in this area was the result of both direct and indirect factors such as weather conditions, the fauna and flora, and last but not least the features of the relief. The augmentation of the processes that stimulate the degradation of the pedological resources and of life-supporting attributes are due to anthropogenic factors as well, which leads to unsustainable land exploitation by regional users on the precarious background created by global climate change. These factors are poverty, government policies, industrial activities, incorrect management of land use, deforestation, overgrazing, unsuitable farming and irrigation practices, misuse of chemical fertilisers.

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